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NikR NikR proteins are obligate homotetramers with a central C-terminal metal-binding domain (MBD) connected by flexible linkers to two peripheral N-terminal DNA-binding domains (DBDs) that adopt a ribbon-helix-helix fold

In particular, they stated -Lipoic acid, and even more so its dihydro derivative to which it is rapidly converted after entering cellular metabolism, could act as an antioxidant for ascorbic acid and tocopherols

Li Z, Wang Y, Xu Q, et al

But this creates a one-dimensional view toward such supplements

The absence of reliable early-stage biomarkers and individualized treatment targets underscores the urgent need for innovative approaches capable of comprehensively mapping metabolic perturbations in diabetes